Table II.
Localization of neurotrophins/GDNF and receptors in the human ovary.
| Ligands/Receptors | Localization | Expression | Detection method | References |
|---|---|---|---|---|
| NGF | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Abir et al. (2005) | |
| GCs | Protein | IHC | Abir et al. (2005), Salas et al. (2006) | |
| Antral | ||||
| Follicles | ||||
| GCs | mRNA and Protein | RT-qPCR, IHC | Salas et al. (2006) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| TCs | Protein | IHC | Salas et al. (2006) | |
| FF | Protein | ELISA | Palumbo et al. (2013) | |
| (213.76 pg/ml, ranged from 100 to 360 pg/ml) | ||||
| BDNF | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Harel et al. (2006) | |
| GCs | Protein | IHC | Harel et al. (2006) | |
| Antral | ||||
| Follicles | ||||
| GCs | mRNA and Protein | RT-qPCR, IHC | Zhao et al. (2011) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| FF | Protein | ELISA | Seifer et al. (2002) | |
| (645.2 ± 23.6 pg/ml)a | ||||
| NT-3 | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Oron et al. (2011) | |
| GCs | Protein | IHC | Oron et al. (2011) | |
| Antral | ||||
| Follicles | ||||
| GCs | Protein | IHC | Seifer et al. (2006) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| FF | Protein | ELISA | Seifer et al. (2002) | |
| (509 ± 97 pg/ml)a | ||||
| NT-4 | Preantral | |||
| Follicles | ||||
| Oocytes | mRNA and protein | ISH, IHC | Anderson et al. (2002), Harel et al. (2006) | |
| Pre-GCs | mRNA and protein | ISH, IHC | Anderson et al. (2002) | |
| GC | Protein | IHC | Harel et al. (2006) | |
| Antral | ||||
| Follicles | ||||
| CCs | Protein | IHC | Seifer et al. (2006) | |
| FF | Protein | ELISA | Seifer et al. (2002) | |
| (397 ± 71 pg/ml)a | ||||
| TrkA | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Abir et al. (2005) | |
| GCs | Protein | IHC | Abir et al. (2005), Salas et al. (2006) | |
| Antral | ||||
| Follicles | ||||
| Oocytes | Protein | IHC | Seifer et al. (2006) | |
| GCs | mRNA and Protein | RT-qPCR, IHC | Salas et al. (2006) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| TCs | Protein | IHC | Salas et al. (2006) | |
| TrkB | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Anderson et al. (2002), Harel et al. (2006) | |
| Pre-GCs | Protein | IHC | Anderson et al. (2002) | |
| GC | Protein | IHC | Harel et al. (2006) | |
| Antral | ||||
| Follicles | ||||
| Oocytes | Protein | IHC | Seifer et al. (2006) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| TrkC | Preantral | |||
| Follicles | ||||
| Oocytes | mRNA and Protein | ISH, IHC | Oron et al. (2011) | |
| GCs | mRNA and Protein | ISH, IHC | Oron et al. (2011) | |
| Antral | ||||
| Follicles | ||||
| Oocytes | Protein | IHC | Seifer et al. (2006) | |
| CCs | Protein | IHC | Seifer et al. (2006) | |
| p75NTR | Preantral | |||
| Follicles | ||||
| Stroma | Protein | IHC | Anderson et al. (2002), Abir et al. (2005) | |
| Antral | ||||
| Follicles | ||||
| TCs | Protein | IHC | Anesetti et al. (2001) | |
| GDNF | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Farhi et al. (2010) | |
| GCs | Protein | IHC | Farhi et al. (2010) | |
| Stroma | Protein | IHC | Farhi et al. (2010) | |
| Antral | ||||
| Follicles | ||||
| Oocytes | Protein | IHC | Farhi et al. (2010) | |
| GCs | mRNA and Protein | RT-qPCR, IHC | Farhi et al. (2010), Zhao et al. (2011) | |
| FF | Protein | ELISA | Kawamura et al. (2008) | |
| (0.4–10.8 ng/ml) | ||||
| GFRα1 | Preantral | |||
| Follicles | ||||
| Oocytes | mRNA and Protein | ISH, IHC | Farhi et al. (2010) | |
| GCs | mRNA and Protein | ISH, IHC | Farhi et al. (2010) | |
| Stroma | Protein | IHC | Farhi et al. (2010) | |
| Antral | ||||
| Follicles | ||||
| Oocytes | Protein | IHC | Farhi et al. (2010) | |
| GCs | Protein | IHC | Farhi et al. (2010) | |
| CCs | mRNA | RT-qPCR | Cui et al. (2018) | |
| RET | Preantral | |||
| Follicles | ||||
| Oocytes | Protein | IHC | Farhi et al. (2010) | |
| GCs | Protein | IHC | Farhi et al. (2010) | |
| Stroma | Protein | IHC | Farhi et al. (2010) | |
| Antral | ||||
| Follicles | ||||
| CCs | mRNA | RT-qPCR | Cui et al. (2018) |
CCs, Cumulus cells; GCs, Granulosa cells; TCs, Theca cells; RT-qPCR, Quantitative real-time PCR; FF, Follicular fluid; ISH, in situ hybridization; IHC, Immunohistochemistry.
aData are expressed as the mean ± SD.