Figure 4.

DCA administration does not interfere with memory retrieval. MWM performed by mice intraperitoneally injected with saline or DCA (200 mg/kg) on the probe trial. A, Mice were trained for 4 consecutive days (4 trials/d) to find the location of a hidden platform in the southwest quadrant, and the latency to escape was recorded. B–G, On day 5, a probe trial was performed in which the platform was removed and mice were allowed to swim for 60 s. B, The swim path for each group of mice was recorded and compiled into heat map representations. C–E, Measurements were taken for the total distance traveled (C), the percentage of time spent in the correct quadrant (D), and the number of times the boundary of the platform was crossed (E). F, Immediately after the probe trial, a flag trial was performed and the latency to find the flag was recorded. Data shown are the mean ± SEM. n = 9 and 10 for saline and DCA treatments, respectively. No significant differences were observed between saline-treated (sham) and DCA-injected mice.