Table 3.

Classification of phospholipid species based on the number of double bonds (degree of fatty acid saturation) in the hippocampus of PSAPP mice.

Significant changes in PC, SM, PE, and PI species with ‘0’, ‘1,’ or ‘3 or more’ double bonds in the hippocampus of an AD mouse model. Sample size for all groups across all time points is n = 4. All data represents mean μM per (5.5 mg) wet weight ± SEM. Individual molecular lipid species were quantified by LC/MS and were summed after LipidomeDB analyses to generate degree of fatty acid classification for each phospholipid species. Blue color code indicates an increase in lipid species. Asterisks represents ^∗∗∗P < 0.001 for comparisons between PSAPP/WT mice. PE, Phosphatidylethanolamine; LPE, Lysophosphatidylethanolamine; PC, Phosphatidylcholine; LPC, Lysophosphatidylcholine; PI, Phosphatidylinositol; SM, Sphingomyelin.