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. 2019 Feb 25;15:1744806919830240. doi: 10.1177/1744806919830240

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Location of injection cannula track. (a) Left panel: a histological section showing the location of injection cannula track. Arrow indicates cannula track. AQ: cerebral aqueduct. Right panel showing a rectangle area selected for the photograph of a histological section. (b) Mechanical and thermal sensitivity in control rats and bone cancer rats. With the development of bone cancer, PWT and PWL were decreased as compared with control rats. Significant mechanical and thermal hyperalgesia appeared seven days after inoculation of cancer cells. The effects of blocking PI3K–mTOR in the dl-PAG on pain responses to mechanical and thermal stimulation were further determined. Blocking respective mTOR and PI3K by infusion of rapamycin and LY294002 into the PAG attenuated hypersensitive pain responses in bone cancer rats. *P < 0.05 versus control rats and bone cancer rats that received infusion of inhibitors. P values are shown. The number of animals is also indicated. dl-PAG: dorsolateral PAG.