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. 2019 Feb 25;15:1744806919830240. doi: 10.1177/1744806919830240

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — PIC levels and PIC receptor expression. (a) The levels of PICs were increased in the dl-PAG of bone cancer rats as compared with control rats (n = 15 in each group). *P < 0.01 versus control rats. P values are also shown. (b and c) Averaged data and typical bands showing the protein expression of PIC receptors (IL-1R, IL-6R, and TNFR1) in the dl-PAG. The expression levels of membrane PIC receptor were amplified in the PAG of bone cancer rats. *P < 0.01 versus control rats. The number of animals = 8–12 in each group. P values are also shown. PIC: pro-inflammatory cytokine; IL: interleukin; TNF: tumor necrosis factor; TNFR1: tumor necrosis factor receptor 1.