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. 2019 Feb 19;10:132. doi: 10.3389/fphys.2019.00132

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Copyright © 2019 Mancini, Vitucci, Randers, Schmidt, Hagman, Andersen, Imperlini, Mandola, Orrù, Krustrup and Buono.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular network generated by the Ingenuity software from the differentially expressed genes in the skeletal muscle from VPG vs CG subjects. The main functional pathways given by Ingenuity for this molecular network are: (A) “Nucleic Acid, amino acid, and protein Metabolism.” Highlights in this network are the RAD23A, HSPB6, HSB1, Rab1B, TRAP1, SIRT2 genes that are all correlated with increase in auto-lysosomal and proteasome-mediated protein degradation machinery and maintenance of protein quality control. (B) “Organ Morphology; Nervous System Development; and Function.” Highlights in this network are ribosomal proteins: RPLP1, RPL4, RPL36, MRLP37 that are involved in cellular growth and proliferation pathways. In red up-regulated and in green down-regulated messenger expression is shown.