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. 2019 Feb 26;10:11. doi: 10.1186/s13293-019-0225-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Sex-dependent inflammatory response to obesity in liver, gAT and iAT. Representative histological sections of staining for F4/80 (n = 4) and relative mRNA expression level of inflammatory genes in a liver b gAT and c iAT; and b gAT and c iAT quantification of crown like structures in F (♀ - open bars and pink bullets) and M (♂ gray bars and blue triangles) mice (n = 7). Values are mean ± sem, n = 6–9; *, P < 0.05, **, P < 0.01, ***, P < 0.001 and ****, P < 0.0001 M vs F were considered significant. Tnfα tumor necrosis factor alfa, Il interleukin, Clec4f C-type lectin domain family 4 member F, Cd68 cluster of differentiation 68, Ccl chemokine (C-C motif) ligand and Mcp Monocyte chemoattractant protein