Table 5.
Subgroup analysis of the association between WCRF/AICR recommendation adherence composite score and risk of any cancer in participants with and without baseline chronic conditions in Alberta’s Tomorrow Project participants
| Baseline health condition/participants | No. of cancer cases | HR* | 95 % CI |
|---|---|---|---|
| With chronic conditions† at baseline | |||
| All (n 11 330) | 1165 | 0·97 | 0·92, 1·03 |
| Men (n 4564) | 523 | 0·96 | 0·88, 1·04 |
| Women (n 6766) | 642 | 0·98 | 0·91, 1·06 |
| Without chronic conditions† at baseline | |||
| All (n 13 770) | 901 | 0·93 | 0·87, 0·98 |
| Men (n 4749) | 337 | 1·01 | 0·92, 1·12 |
| Women (n 9021) | 564 | 0·87 | 0·80, 0·94 |
| With high blood pressure or high cholesterol or diabetes at baseline | |||
| All (n 10 162) | 1049 | 0·98 | 0·92, 1·04 |
| Men (n 4176) | 472 | 0·97 | 0·89, 1·05 |
| Women (n 5986) | 577 | 0·99 | 0·91, 1·07 |
| Without high blood pressure or high cholesterol or diabetes at baseline | |||
| All (n 14 938) | 1017 | 0·92 | 0·87, 0·98 |
| Men (n 5137) | 388 | 0·99 | 0·91, 1·09 |
| Women (n 9801) | 629 | 0·87 | 0·81, 0·94 |
WCRF/AICR, World Cancer Research Fund/American Institute for Cancer Research; HR, hazard ratio.
HR were estimated using a Cox regression model by each one additional recommendation met, adjusted for age (continuous in years), sex (only in sex combined model), marital status (living without partner, living with partner), education level (high school or lower, college, university), employment status (not employed, retired, employed part-time, employed full-time), annual household income (<$CAN 70 000, ≥$CAN 70 000), first-degree family history of cancer (no, yes), as well as hormone replacement therapy in women.
If participants reported having a personal history of any one of the following medical conditions: high blood pressure, angina, high cholesterol in blood, heart attack, stroke, emphysema, chronic bronchitis, diabetes, ulcerative colitis, Crohn’s disease, hepatitis or liver cirrhosis.