Table 4.
Growth curve models for SIB-S total and domain scores
| Total SIB-S | Semantic memory | Episodic memory | M-O-ATT | |
|---|---|---|---|---|
| Effect of Time for the whole sample | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant | 27.902(1.073) | 17.122(.734) | 1.555(.096) | 6.199(.264) |
| Age (centered) | .041 (.155) | .030(.105) | −.018(.013) | .008(.038) |
| Time (days from T0) | −.012(.001) *** | −.008(.001) *** | −.0008(.0002) *** | −.002(.0003) *** |
| Effect of Time² for the whole sample | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant | 27.748(1.082) | 17.060(.740) | 1.499(.099) | 6.157(.268) |
| Age (centered) | .042(.155) | .030(.105) | −.018(.013) | .008(.038) |
| Time (days from T0) | − .009(.003) ** | −.006(.002) ** | .0002(.0005) | −.002(.001) |
| Time² | <−.0001(<.0001) | < .0001(<.0001) | < .0001(<.0001) * | < .0001(<.0001) |
| Effect of GDS x Time | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant a | 29.896(.999) | 18.369(.713) | 1.558(.110) | 6.523(.257) |
| Age (centered) | .171(.102) | .113(.072) | −.010(.010) | .042(.026) |
| Time (days from T0) a | −.018(.002) *** | −.012(.001) *** | −.001(.0002) *** | −.004(.0006) *** |
| GDS (6 compared to 5) | 11.434(1.673) *** | 7.705(1.194) *** | 1.126(.184) *** | 3.062(.431) *** |
| GDS (6 compared to 7) | −21.970(1.774) *** | −14.380(1.267) *** | −1.334(.196) *** | −4.903(.457) *** |
| GDS (7 compared to 5) | 33.404(1.984) *** | 22.086(1.417) *** | 2.460(.218) *** | 7.966(.512) *** |
| GDS (6 compared to 5) × Time | .009(.003) ** | .006(.002) ** | .0002(.0004) | .001(.0009) |
| GDS (6 compared to 7) × Time | .013(.003) *** | .009(.002) *** | .0009(.0004) * | .003(.0009) ** |
| GDS (7 compared to 5) × Time | −.004(.004) | −.003(.003) | −.0007(.0004) | −.002(.001) |
| Effect of Time for GDS-score 5 | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant | 41.330(.910) | 26.033(.693) | 2.682(.152) | 9.591(.259) |
| Age (centered) | −.127(.134) | −.079(.097) | −.048(.021) * | −.042(.038) |
| Time (days from T0) | −.008(.003) ** | −.004(.002) | −.0008(.0003) ** | −.002(.0007) ** |
| Effect of Time for GDS-score 6 | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant | 30.046(1.177) | 18.472(.848) | 1.570(.127) | 6.560(.297) |
| Age (centered) | .421(.181) * | .293(.130) * | .011(.018) | .103(.045) * |
| Time (days from T0) | −.018(.002) *** | −.012(.002) *** | −.001(.0003) *** | −.004(.0007) *** |
| Effect of Time for GDS-score 7 | ||||
| Fixed effects (coefficients and SE) | ||||
| Constant | 8.045(1.271) | 4.071(.789) | .210(.066) | 1.643(.324) |
| Age (centered) | .031(.154) | .011(.095) | −.008(.007) | .012(.039) |
| Time (days from T0) | −.004(.001) ** | −.002(.001) * | −.0002(.0002) | −.0007(.0005) |
Note. GDS-score 5, moderate dementia; GDS-score 6, moderately severe dementia; GDS-score 7, severe cognitive decline/late dementia
a
Group with GDS-score 6 was used as reference group.
*
p < .05.
**
p < . 01.
***
p < .001.
SIB-S, Severe Impairment Battery Short version; M-O-ATT, Memory-Orientation-Attention domain.