Table 3.
Diet specifications (g/4184 kJ (1000 kcal)) | Time to peak plasma: mean peak plasma P (mmol/l) | Mean P AUC (mmol/l × h) | Ionised Ca area between baseline and curve (mmol/l × h) | Peak PTH (pg/ml) | Mean urine P excretion (mg/kg BW) | Mean P intake over sample day (mg/kg BW) | Test diet P intake (mg/kg BW) | Test diet added P intake (mg/kg BW) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | Mean | 95 % CI | |
Diet A: total P 4·78 g, 3·5 g from SDHP, Ca:P 0·59 | 150 min*: 1·976 | 150 min: 1·724, 2·266 | 3·65a | 2·80, 4·49 | –0·337a | –0·495, –0·178 | 31·83a | 24·32, 41·67 | 56·6a | 45·1, 68·2 | 161·24 | 153·09, 169·39 | 100·98 | 86·67, 117·62 | 72·63 | 63·43, 83·15 |
Diet B: total P 3·38 g, no added inorganic P, Ca:P 1·55 | 0 min (no peak): 1·211 | 0 min (no peak): 1·053, 1·392 | –1·1b | –1·4, –0·621 | –0·145b | –0·285, –0·00553 | 8·07b | 6·11, 10·65 | 29·2b | 17·4, 41·0 | 130·80 | 123·72, 137·87 | 68·37 | 58·64, 79·69 | 0 | |
Diet C: total P 1·13 g, no added inorganic P, Ca:P 1·23 | 0 min (no peak): 1·24 | 0 min (no peak): 1·14, 1·35 | –1·01a | –1·4, –0·621 | –0·26a | –0·347, –0·174 | 9·17a | 7·58, 11·1 | 28·4a | 21·0, 35·9 | 89·21 | 80·67, 97·75 | 25·56 | 22·80, 28·64 | 0 | |
Diet D: total P 4·02, 0·5 g from STPP, Ca:P 1·63 | 120 min*: 1·26 | 120 min: 1·16, 1·37 | –0·516b | –0·896, –0·136 | –0·278a | –0·368, –0·189 | 11·6b | 9·6, 14·0 | 30·2a | 23·3, 37·1 | 150·48 | 141·94, 159·02 | 87·29 | 78·12, 97·52 | 22·42 | 20·26, 24·81 |
Diet E: total P 4·48 g, 0·75 g from STTP, Ca:P 1·59 | 120 min*: 1·32 | 120 min: 1·21, 1·44 | –0·197b | –0·585, 0·191 | –0·26a | –0·35, –0·17 | 14·0b,c | 11·5, 17·0 | 35·2a | 28·0, 42·3 | 161·09 | 152·55, 169·64 | 94·05 | 84·18, 105·07 | 33·67 | 30·47, 37·20 |
Diet F: total P 4·48 g, 1 g from STPP, Ca:P 1·48 | 120 min*: 1·5 | 120 min: 1·38, 1·63 | –0·151b | –0·539, 0·236 | –0·253a | –0·336, –0·17 | 16·0c,d | 13·2, 19·3 | 32·2a | 25·0, 39·4 | 159·28 | 150·73, 167·82 | 96·68 | 86·54, 108·01 | 45·19 | 40·92, 49·88 |
Diet G: total P 4·9 g, 1·5 g from STPP, Ca:P 1·64 | 120 min*: 1·63 | 120 min: 1·50, 1·78 | 0·35c | –0·0305, 0·731 | –0·344a | –0·448, –0·241 | 20·4e | 16·9, 24·6 | 37·3a | 29·8, 44·7 | 168·49 | 159·95, 177·03 | 102·25 | 91·53, 114·22 | 67·05 | 60·77, 73·98 |
Diet H: total P 3·79 g, no added inorganic P, Ca:P 1·6 | 360 min: 1·24 | 360 min: 1·13, 1·36 | –0·277a | –0·688, 0·134 | –0·0963a | –0·157, –0·0351 | 7·46a | 6·13, 9·07 | 26·58a | 20·54, 32·62 | 138·99 | 130·62, 147·36 | 77·06 | 69·32, 85·64 | 0 | |
Diet I: total P 3·86 g, 1·5 g from SDHP, Ca:P 1·59 | 110 min*: 1·40 | 110 min: 1·28, 1·54 | 0·48b | –0·00355, 0·82 | –0·165a | –0·226, –0·104 | 9·18b | 7·57, 11·13 | 27·76a | 21·69, 33·83 | 136·23 | 126·50, 145·97 | 74·64 | 67·15, 82·96 | 29·20 | 26·54, 32·12 |
Diet J: total P 3·52 g, 1·5 g from STPP, Ca:P 1·7 | 60 min*: 1·40 | 60 min: 1·28, 1·53 | –0·146a | –0·558, 0·265 | –0·198b | –0·259, –0·137 | 9·07b | 7·45, 11·03 | 25·36a | 19·32, 31·40 | 132·67 | 123·64, 141·70 | 70·87 | 63·75, 78·78 | 30·12 | 27·38, 33·13 |
Diet K: total P 3·59, 1·5 g from SDHP, Ca:P 0·93 | 360 min*: 1·57 | 360 min: 1·44, 1·70 | 1·25a | 0·629, 1·86 | –0·24a | –0·31, –0·169 | 7·81a,b | 6·00, 10·20 | 38·1a | 28·7, 47·6 | 149·76 | 139·40, 159·82 | 86·74 | 75·85, 99·18 | 33·98 | 30·11, 38·33 |
Diet L: total P 4·17 g, 1·5 g from STPP, Ca:P 1·88 | 110 min*: 1·5 | 110 min: 1·36, 1·64 | –0·241b | –0·882, 0·400 | – 0·265a | –0·339, –0·192 | 8·89a,b | 6·77, 11·70 | 31·0a | 21·0, 41·0 | 155·63 | 139·16, 172·09 | 91·00 | 79·14, 104·61 | 32·81 | 28·93, 37·20 |
Diet M: total P 5·5 g, 1·5 g from STPP, Ca:P 1·7 | 110 min*: 1·51 | 110 min: 1·37, 1·65 | 0·0868b | –0·554, 0·728 | –0·231b | –0·304, –0·158 | 10·60a | 8·09, 14·00 | 40·9a | 29·4, 52·4 | 184·09 | 166·78, 201·41 | 119·79 | 104·22, 137·66 | 32·07 | 28·27, 36·35 |
Diet N: total P 4·85 g, 0·5 g from STPP, Ca:P 1·47 | 0 min (no peak): 1·31 | 0 min (no peak): 1·17, 1·45 | –0·577b | –1·24, 0·0895 | –0·238a | –0·315, –0·162 | 7·23b | 5·41, 9·67 | 33·5a | 22·8, 44·1 | 151·14 | 129·97, 172·30 | 83·43 | 72·10, 96·53 | 8·71 | 7·55, 10·03 |
PTH, parathyroid hormone; BW, body weight; SDHP, sodium dihydrogen phosphate; STPP, sodium tripolyphosphate.
a,b,c,d,e Mean values with unlike superscript letters were significantly different between diets within each study (P <0·05).
Time to peak plasma shows significant difference to baseline results.
Separate trials are delineated by a blank line.