Flowchart of the study design. BT1, bronchial thermoplasty session 1, treatment of the right lower lobe (RLL); BT2, bronchial thermoplasty session 2, treatment of the left lower lobe (LLL); BT3, bronchial thermoplasty session 3, treatment of the right upper lobe (RUL) and left upper lobe (LUL); OCT, optical coherence tomography; RML, right middle lobe; CT, computed tomography.