Table 3. Group II click products 46–57 of halogenated azidomethylsulfoxides 11, 12 and azidophenyl sulfones 14, 15 with selected arylacetylenes 17–19.
| |
Compound | Yield a (%) |
46, R1 = 4-fluorophenyl, R2 = 3-fluorophenyl, R3 = SO | 78 |
47, R1 = 4-fluorophenyl, R2 = 4-fluorophenyl, R3 = SO | 83 |
48, R1 = 4-fluorophenyl, R2 = 2-methoxypheny, R3 = SO | 92 |
49, R1 = 4-chlororophenyl, R2 = 3-fluorophenyl, R3 = SO | 52 |
50, R1 = 4-chlorophenyl, R2 = 4-fluorophenyl, R3 = SO | 93 |
51, R1 = 4-chlorophenyl, R2 = 2-methoxyphenyl, R3 = SO | 76 |
52, R1 = 4-fluorophenyl, R2 = 3-fluorophenyl, R3 = SO2 | 79 |
53, R1 = 4-fluorophenyl, R2 = 4-fluorophenyl, R3 = SO2 | 83 |
54, R1 = 4-fluorophenyl, R2 = 2-methoxyphenyl, R3 = SO2 | 95 |
55, R1 = 4-chlororophenyl, R2 = 3-fluorophenyl, R3 = SO2 | 84 |
56, R1 = 4-chlorophenyl, R2 = 4-fluorophenyl, R3 = SO2 | 93 |
57, R1 = 4-chlorophenyl, R2 = 2-methoxyphenyl, R3 = SO2 | 81 |
aYields are for isolated pure compounds.