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. 2019 Jan 15;10(2):268–279. doi: 10.1039/c8md00405f

Table 4. Group III click products of azides 73–87 and acetylenes 25–27.

Inline graphic
Compound Yield a (%)
90, R1 = phenyl, R2 = 3-triazolyl, R3, R4 = ethyl 76
91, R1 = phenyl, R2 = 4-triazolyl, R3, R4 = ethyl 90
92, R1 = 4-fluorophenyl, R2 = 3-triazolyl, R3, R4 = ethyl 48
93, R1 = 4-fluorophenyl, R2 = 4-triazolyl, R3, R4 = ethyl 45
94, R1 = 4-chlorophenyl, R2 = 3-triazolyl, R3, R4 = ethyl 52
95, R1 = 4-chlorophenyl, R2 = 4-triazolyl, R3, R4 = ethyl 57
96, R1 = 4-methoxyphenyl, R2 = 3-triazolyl, R3, R4 = ethyl 53
97, R1 = 4-methoxyphenyl, R2 = 4-triazolyl, R3, R4 = ethyl 63
98, R1 = 2-furyl, R2 = 3-triazolyl, R3, R4 = ethyl 52
99, R1 = 2-furyl, R2 = 4-triazolyl, R3, R4 = ethyl 46
100, R1 = phenyl, R2 = 3-triazolyl, R3 = 2-fluorophenyl, R4 = H 80
101, R1 = phenyl, R2 = 4-triazolyl, R3 = 2-fluorophenyl, R4 = H 65
102, R1 = 4-fluorophenyl, R2 = 3-triazolyl, R3 = 2-fluorophenyl, R4 = H 95
103, R1 = 4-fluorophenyl, R2 = 4-triazolyl, R3 = 2-fluorophenyl, R4 = H 77
104, R1 = 4-chlorophenyl, R2 = 3-triazolyl, R3 = 2-fluorophenyl, R4 = H 70
105, R1 = 4-chlorophenyl, R2 = 4-triazolyl, R3 = 2-fluorophenyl, R4 = H 69
106, R1 = 4-methoxyphenyl, R2 = 3-triazolyl, R3 = 2-fluorophenyl, R4 = H 66
107, R1 = 4-methoxyphenyl, R2 = 4-triazolyl, R3 = 2-fluorophenyl, R4 = H 75
108, R1 = 2-furyl, R2 = 3-triazolyl, R3 = 2-fluorophenyl, R4 = H 69
109, R1 = 2-furyl, R2 = 4-triazolyl, R3 = 2-fluorophenyl, R4 = H 83
110, R1 = phenyl, R2 = 2-triazolyl, R3 = 4-fluorophenyl, R4 = H 30
111, R1 = phenyl, R2 = 3-triazolyl, R3 = 4-fluorophenyl, R4 = H 82
112, R1 = phenyl, R2 = 4-triazolyl, R3 = 4-fluorophenyl, R4 = H 48
113, R1 = 4-fluorophenyl, R2 = 2-triazolyl, R3 = 4-fluorophenyl, R4 = H 77
114, R1 = 4-fluorophenyl, R2 = 3-triazolyl, R3 = 4-fluorophenyl, R4 = H 87
115, R1 = 4-fluorophenyl, R2 = 4-triazolyl, R3 = 4-fluorophenyl, R4 = H 26
116, R1 = 4-chlorophenyl, R2 = 2-triazolyl, R3 = 4-fluorophenyl, R4 = H 83
117, R1 = 4-chlorophenyl, R2 = 3-triazolyl, R3 = 4-fluorophenyl, R4 = H 55
118, R1 = 4-chlorophenyl, R2 = 4-triazolyl, R3 = 4-fluorophenyl, R4 = H 51
119, R1 = 4-methoxyphenyl, R2 = 2-triazolyl, R3 = 4-fluorophenyl, R4 = H 43
120, R1 = 4-methoxyphenyl, R2 = 3-triazolyl, R3 = 4-fluorophenyl, R4 = H 77
121, R1 = 4-methoxyphenyl, R2 = 4-triazolyl, R3 = 4-fluorophenyl, R4 = H 67
122, R1 = 2-furyl, R2 = 2-triazolyl, R3 = 4-fluorophenyl, R4 = H 49
123, R1 = 2-furyl, R2 = 3-triazolyl, R3 = 4-fluorophenyl, R4 = H 69
124, R1 = 2-furyl, R2 = 4-triazolyl, R3 = 4-fluorophenyl, R4 = H 68

aYields are for isolated purified compounds.