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The IC50 values of free drug CPT/CisPt(II) combinations and mixed polymer-drug micelles M[CPT/CisPt(II)] with various CPT/CisPt(II) ratios evaluated in HCT-8 cells at 48 h.
| Free drug combinations | IC50 (μmol/L) | Polymer-drug Micelles | IC50 (μmol/L) |
|---|---|---|---|
| CisPt(II) | 13.66 | M[CisPt(II)] | 21.47 |
| CPT0.1/Pt | 9.62 | M(CPT0.1/Pt) | 13.82 |
| CPT0.2/Pt | 7.74 | M(CPT0.2/Pt) | 11.55 |
| CPT0.5/Pt | 5.03 | M(CPT0.5/Pt) | 7.40 |
