Table 3.

Minor allele frequencies (MAFs) of COMT SNPs in subjects diagnosed with fibromyalgia (FM) compared with those of US populations from the 1000 Genomes Project (1000G-US)

SNP/Population	Minor Allele Frequency
	1000G-US	FM Group	Direction	Model β	P-value
rs6269 (A > G)	0.36	0.39	↑	− 0.03	2.40 × 10− 6
African-American	0.34	0.38	↑	− 0.04	0.023
Caucasian	0.44	0.41	↓	0.03	1.69 × 10− 4
Hispanic	0.27	0.28		−0.01	0.580
Females	0.34	0.39	↑	−0.05	1.69 × 10−12
African-American	0.29	0.38	↑	−0.09	6.04 × 10−7
Caucasian	0.41	0.40		0.01	0.472
Hispanic	0.28	0.27		0.01	0.831
Males	0.39	0.40		−0.01	0.540
African-American	0.40	0.36		0.04	0.145
Caucasian	0.47	0.42	↓	0.05	0.002
Hispanic	0.25	0.30		−0.05	0.347
rs4633 (C > T)	0.41	0.47	↑	−0.06	1.08 × 10−22
African-American	0.32	0.33		−0.01	0.583
Caucasian	0.46	0.51	↑	−0.05	3.04 × 10−8
Hispanic	0.40	0.43		−0.03	0.348
Females	0.41	0.48	↑	−0.07	7.16 × 10−20
African-American	0.33	0.33		0	0.838
Caucasian	0.48	0.52	↑	−0.04	6.25 × 10−5
Hispanic	0.38	0.44		−0.06	0.064
Males	0.41	0.46	↑	−0.05	8.18 × 10−5
African-American	0.31	0.32		−0.01	0.695
Caucasian	0.45	0.49	↑	−0.04	0.009
Hispanic	0.42	0.39		0.03	0.601
rs4818 (C > G)	0.32	0.36	↑	−0.04	2.15 × 10−9
African-American	0.21	0.19		0.02	0.185
Caucasian	0.44	0.40	↓	0.04	1.69 × 10−5
Hispanic	0.24	0.27		−0.03	0.245
Females	0.31	0.36	↑	−0.05	1.17 × 10−9
African-American	0.23	0.19	↓	0.04	0.024
Caucasian	0.41	0.40		0.01	0.356
Hispanic	0.25	0.26		−0.01	0.672
Males	0.33	0.36	↑	−0.03	0.006
African-American	0.19	0.21		−0.02	0.573
Caucasian	0.47	0.41	↓	0.06	1.19 × 10−4
Hispanic	0.23	0.30		−0.07	0.201
rs4680 (G > A)	0.39	0.47	↑	−0.08	5.62 × 10−31
African-American	0.27	0.31	↑	−0.04	0.006
Caucasian	0.46	0.51	↑	−0.05	1.36 × 10−7
Hispanic	0.40	0.44		−0.04	0.187
Females	0.40	0.48	↑	−0.08	4.82 × 10−23
African-American	0.29	0.31		−0.02	0.145
Caucasian	0.48	0.52	↑	−0.04	1.67 × 10−4
Hispanic	0.39	0.45		−0.06	0.088
Males	0.39	0.46	↑	−0.07	4.35 × 10−8
African-American	0.25	0.32	↑	−0.07	0.025
Caucasian	0.45	0.49	↑	−0.04	0.012
Hispanic	0.41	0.41		0	0.988

Comparisons that are statistically significant (p ≤ 0.05) are indicated with direction of increased or decreased frequency of MAF. Model β coefficients are the effect sizes. Differences between groups delineated by both sex and ethnicity are graphically shown in Fig. 2