Table 2.

Agreement between different definitions of response and remission

	Physician-perceived remission	Patient-perceived remission	DAS44 remission	EULAR good response	ACR70 response	Boolean remission
Physician- perceived remission	x	67%	74%	79%	60%	57%
		Ƙ = 0.318	Ƙ = 0.439	Ƙ = 0.484	Ƙ = 0.281	Ƙ = 0.248
		P = 0.003	P < 0.001	P < 0.001	P = 0.001	P = 0.002
Patient-perceived remission	67%	x	46%	69%	69%	67%
	Ƙ = 0.318		Ƙ = 0.516	Ƙ = 0.356	Ƙ = 0.398	Ƙ = 0.354
	P = 0.003		P < 0.001	P < 0.001	P < 0.001	P < 0.001
DAS44 remission	74%	46%	x	83%	64%	67%
	Ƙ = 0.439	Ƙ = 0.516		Ƙ = 0.622	Ƙ = 0.343	Ƙ = 0.392
	P < 0.001	P < 0.001		P < 0.001	P < 0.001	P < 0.001
EULAR good response	79%	69%	83%	x	52%	50%
	Ƙ = 0.484	Ƙ = 0.356	Ƙ = 0.622		Ƙ = 0.220	Ƙ = 0.199
	P < 0.001	P < 0.001	P < 0.001		P = 0.001	P = 0.002
ACR70 response	60%	69%	64%	52%	x	74%
	Ƙ = 0.281	Ƙ = 0.398	Ƙ = 0.343	Ƙ = 0.220		Ƙ = 0.359
	P = 0.001	P < 0.001	P < 0.001	P = 0.001		P = 0.001
Boolean remission	57%	67%	67%	50%	74%	x
	Ƙ = 0.248	Ƙ = 0.354	Ƙ = 0.392	Ƙ = 0.199	Ƙ = 0.359
	P = 0.002	P < 0.001	P < 0.001	P = 0.002	P = 0.001

Numbers are presented as level of agreement (%), kappa value (K) and p-value (P)

Physician-perceived remission was defined as a VAS of ≤10 mm as answer to the question: “How active do you think the rheumatoid arthritis of your patient is today?”

Patient-perceived remission was defined as “yes” or “no” as answer to the question: “Would you say that, at this moment, your disease activity is as good as gone?”

ACR70 American College of Rheumatology 70 response, DAS44 disease activity score of 44 joints, EULAR European League Against Rheumatism, mm millimeter