Table 4.
Associations of DAS28-related variables with DAS28-ESR and CRP
| BSRBR anti-TNF | BSRBR-Control | ERAN | |||||
|---|---|---|---|---|---|---|---|
| B (95% CI) | p | B (95% CI) | p | B (95% CI) | p | ||
| DAS28 | TJC | 0.72 (0.71 to 0.73) | < 0.001 | 0.76 (0.74 to 0.78) | < 0.001 | 0.59 (0.55 to 0.62) | < 0.001 |
| VAS-GH | 0.49 (0.47 to 0.50) | < 0.001 | 0.62 (0.59 to 0.65) | < 0.001 | 0.46 (0.42 to 0.51) | < 0.001 | |
| SJC | 0.56 (0.55 to 0.58) | < 0.001 | 0.60 (0.58 to 0.62) | < 0.001 | 0.48 (0.45 to 0.52) | < 0.001 | |
| ESR | 0.49 (0.48 to 0.51) | < 0.001 | 0.53 (0.51 to 0.56) | < 0.001 | 0.41 (0.37 to 0.45) | < 0.001 | |
| DAS28 | Not applicable | ||||||
| DAS28-P | 0.19 (0.17 to 0.20) | < 0.001 | 0.29 (0.26 to 0.32) | < 0.001 | 0.24 (0.19 to 0.29) | < 0.001 | |
| Tender-swollen difference | 0.25 (0.24 to 0.27) | < 0.001 | 0.36 (0.32 to 0.39) | < 0.001 | 0.15 (0.11 to 0.20) | < 0.001 | |
| Tender:swollen ratio | 0.11 (0.09 to 0.12) | < 0.001 | 0.13 (0.10 to 0.16) | < 0.001 | 0.07 (0.02 to 0.12) | 0.011 | |
| CRP | TJC | −0.02 (− 0.05 to 0.01) | 0.161 | 0.09 (0.02 to 0.16) | 0.010 | 0.17 (0.07 to 0.26) | < 0.001 |
| VAS-GH | 0.17 (0.14 to 0.20) | < 0.001 | 0.21 (0.13 to 0.28) | < 0.001 | 0.17 (0.08 to 0.26) | < 0.001 | |
| SJC | 0.10 (0.07 to 0.13) | < 0.001 | 0.11 (0.05 to 0.17) | 0.001 | 0.23 (0.13 to 0.32) | < 0.001 | |
| ESR | 0.58 (0.55 to 0.60) | < 0.001 | 0.56 (0.51 to 0.62) | < 0.001 | 0.62 (0.55 to 0.69) | < 0.001 | |
| DAS28 | 0.36 (0.33 to 0.39) | < 0.001 | 0.47 (0.40 to 0.55) | < 0.001 | 0.45 (0.37 to 0.53) | < 0.001 | |
| DAS28-P | −0.31 (−0.34 to − 0.28) | < 0.001 | − 0.28 (− 0.36 to − 0.20) | < 0.001 | −0.20 (− 0.30 to − 0.11) | < 0.001 | |
| Tender-swollen difference | − 0.10 (− 0.13 to − 0.07) | < 0.001 | −0.01 (− 0.08 to 0.06) | 0.851 | −0.03 (− 0.13 to 0.06) | 0.487 | |
| Tender:swollen ratio | −0.11 (− 0.14 to − 0.08) | < 0.001 | −0.08 (− 0.15 to − 0.01) | 0.020 | −0.08 (− 0.18 to 0.02) | 0.104 | |
Linear regression of z-transformed variables. Regression coefficients (95% CI) and p values for associations with the inflammatory measures, DAS28 and CRP. CRP data were ln-transformed prior to regression analysis. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold