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. 2018 Aug 28;2:23. doi: 10.1186/s41927-018-0031-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Preclinical efficacy of upadacitinib in rat adjuvant induced arthritis model. a Exposure–response relationships for upadacitinib (solid symbols) and tofacitinib (open symbols) in a rat adjuvant-induced arthritis model. b Quantitative effect of upadacitinib on bone erosion as assessed by micro CT scanning. c and d Representative micro CT scans of the tarsal regions of vehicle (c) and adjuvant-induced arthritis rats treated with upadacitinib (d)