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. 2019 Feb 19;13:6. doi: 10.3389/fninf.2019.00006

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Copyright © 2019 Wang, He, Hou, Chui, Gao, Wang, Han and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Coronal MR images demonstrate the process of diffusion and clearance of Gd-DTPA in the ISS of rat brain. After the Gd-DTPA tracer was injected into the ISS, the signal intensity of the caudate nucleus increased, and the hyper-intensity distributed around and the intensity attenuated gradually, which was related to the clearance of Gd-DTPA over time. Moreover, the anisotropic diffusion properties was demonstrated. Gd-DTPA was uniformly dissipated to the anterolateral frontal and temporal cortices and its distribution in posteromedial thalamus was not observed.