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. 2019 Jan 10;10(2):315–325. doi: 10.1039/c8md00545a

Table 1. Affinity of [7]annulenothiophenamines 7a and 8a and reference compounds towards NMDAR and related receptors.

Inline graphic
Compd. X K i ± SEM [nM] (n = 3)
GluN2B σ1 σ2
7a OH 204 ± 81 737 606
8a H 26 ± 3 79 ± 11 50 ± 23
Ifenprodil 10 ± 0.7 125 ± 24 98 ± 34
cis-334 16 ± 3 132 9.2 ± 2.1
trans-334 48 ± 11 167 1100
4 35 57 ± 6.0 107 203
5 36 128 470 770