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. 2019 Feb 19;10:112. doi: 10.3389/fphar.2019.00112

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Copyright © 2019 Murga, Arcones, Cruces-Sande, Briones, Salaices and Mayor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiovascular and metabolic disease-related contexts with increased GRK2 levels and effects of interfering GRK2 expression or functionality. Enhanced GRK2 levels have been reported in different tissues and cell types of patients and/or preclinical models of the indicated situations associated with cardiovascular and metabolic diseases. On the other hand, interfering GRK2 functionality in these settings in preclinical models can modulate different relevant cellular processes implicated in disease development and progression. See text for details.