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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Biochimie. 2018 Jul 24;153:171–180. doi: 10.1016/j.biochi.2018.07.006

Figure 6.

Figure 6.

27-OHC decreases p-AKT. Western blot analysis (A) and optical density analysis (B) showing reduced levels of active p-AKT in Caco2 but not in SW620 cells following treatment with 27-OHC (10μM). Treatment with the AKT inhibitor afuresertib (AF) led to a decrease in cell proliferation in Caco2 cells as shown with an MTT assay compared to untreated (UT) or vehicle treated (Veh) cells (C). A representative Western blot (E) and optical density analyses (F,G,H) showing an increase in p-AKT and a decrease in AKT levels with afuresertib in Caco2 cells. * p <0.05; **p < 0.01.