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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Eur Urol. 2018 Jun 23;74(4):483–486. doi: 10.1016/j.eururo.2018.06.007

FIGURE 2.

FIGURE 2.

Bi-allelic loss of TSC genes activates mTOR pathway in ESC-RCC A. H&E stained section from ESC-RCC showing characteristic morphological features (red star) and background benign renal parenchyma (green star). Scale bar 200 μm. B. Tumor cells diffusely and moderately express phospho-4E-BP1 (red star) with negative expression in the background renal parenchyma (green star). Scale bar 200 μm. C. Tumor cells diffusely and strongly express phospho-S6 Rib P D68.F8 (red star) with weak expression in certain cell types in the background renal parenchyma (green star). Scale bar 200 μm. D. Tumor cells diffusely and strongly express phospho-S6 Rib P D57.2.2E (red star) with weak to moderate expression in certain cell types within the background renal parenchyma (green star). Scale bar 200 μm.