Figure 4.

Bioactivity and biocompatibility of SCS/P composite scaffold.

Notes: (A) SEM image of SCS/P scaffold after immersed in SBF after 7 days. The region of interest is selected by a blue dashed outline and magnified in (B). (C) XRD spectra of SCS/P scaffold immersed in SBF after 7 days (blue line) and untreated by SBF (yellow line). (D) Cell viability and (E) the fold change of BMSCs co-cultured with SCS and SCS/P composite scaffolds. Cells cultured without SCS or SCS/P composite scaffolds were used as control (CON). *P<0.05, compared with the corresponding data at day 1. Abbreviations: SCS/P, silk/calcium silicate/sodium alginate/PVA; SBF, simulated body fluid; CS, calcium silicate; HA, hydroxyapatite; CON, control; SCS, silk/calcium silicate/sodium alginate; SEM, scanning electron microscopy; BMSCs, bone marrow stem cells.