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. 2019 Feb 22;14:1451–1467. doi: 10.2147/IJN.S193544

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© 2019 Xin et al. This work is published and licensed by Dove Medical Press Limited

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Evaluation of new bone formation in calvarial defects at 8 weeks post-implantation via µCT.

Notes: (A) Representative µCT images of calvarial defects showing mineralized bone formation after treatment with no implant (blank), SCS/P scaffold (0), i/SCS/P containing 100 ng irisin (100), and i/SCS/P containing 200 ng irisin (200), respectively. The yellow circle indicates the original defect margin. Scale bar: 1 mm. Quantitative analysis of (B) the volume of the regenerated BV and (C) BMD. *P<0.05, compared with blank and 0 groups.

Abbreviations: µCT, microcomputed tomography; SCS/P, silk/calcium silicate/sodium alginate/PVA; i/SCS/P, irisin-loaded silk/calcium silicate/sodium alginate/PVA; BV, bone volume; BMD, bone mineral density.