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. 2019 Feb 22;14:1451–1467. doi: 10.2147/IJN.S193544

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© 2019 Xin et al. This work is published and licensed by Dove Medical Press Limited

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Histological sections stained with H&E.

Notes: Scaffolds in different groups were implanted at the calvarial defects for 8 weeks. (A) No implant. (B) SCS/P scaffold. (C) i/SCS/P containing 100 ng irisin. (D) i/SCS/P containing 200 ng irisin. The first panel images showed the whole view of the operation site. Higher magnification (×25) of the boxed area is displayed for margin of the defects (green dotted lines) and center of the defects (blue dotted lines). Black arrows represent new blood vessels and endotheliocytes.

Abbreviations: SCS/P, silk/calcium silicate/sodium alginate/PVA; i/SCS/P, irisin-loaded silk/calcium silicate/sodium alginate/PVA.