Table 3.

Common drug-drug interactions of oral anticoagulants

Drug	Increase Anticoagulant Effects	Decrease Anticoagulant Effects
Warfarin	Amiodarone, fluconazole, tigecycline, voriconazole, fluoroquinolones, verapamil, diltiazem, other anticoagulants, antiplatelet drugs, NSAIDs, and SSRIs	Rifampin, phenobarbital, carbamazepine, cigarette smoking
Dabigatran	Amiodarone, verapamil, ketoconazole, dronaderone, clopidogrel, enoxaparin, other anticoagulants, antiplatelet drugs	Rifampin
Apixaban	Ketoconazole, other anticoagulants, antiplatelet drugs	Rifampin
Rivaroxaban	Other anticoagulants, antiplatelet drugs, fluconazole, ketoconazole, erythromycin, and clarithromycin	Rifampin, phenytoin, carbamazepine, St. John’s Wort
Edoxaban	Other anticoagulants, antiplatelet drugs,	Rifampin

NSAID, nonsteroidal anti-inflammatory drug; SSRI, serotonin reuptake inhibitor.