Table 4.

Reversal agents for oral anticoagulants and hemodialysis as an option to reverse antithrombotic effects

Reversal modality	Warfarin	Dabigatran	Rivaroxaban	Apixaban	Edoxaban
Reversal by antidotes
Prothrombin complex concentrate	Yes	No	Yes	Yes	Yes
Recombinant factor VIIa	Yes	No	Yes	Yes	Yes
Fresh frozen plasma	Yes	No	Yes	Yes	Yes
Factor VIII inhibitor bypass activity	Not reported	Yes	Yes	Yes	Yes
Specific antidote	No	Idaracizumab	Investigational (andexanet alfa)
Dialysis as a treatment option for  major bleeding events
Hemodialysis	No	Yes	No	No	No