Figure 4.

Genetic testing and pathology can be complementary tests to improve interpretation. Kidney pathology in a female (7939) with a likely pathogenic variant in COL4A3. (A) The glomeruli show mildly thickened capillary walls and no segmental scarring (in 53 glomeruli available for light microscopy; periodic acid-Schiff staining, x40 magnification). (B) Ultrastructural examination confirms thickened glomerular basement membranes, at approximately two-fold, and demonstrates extensive podocyte foot process effacement, at approximately 80% (×4000 magnification).