Table 1. From prototypes to a universal tool box for generating recombinant B cell epitope-based allergy vaccines.

Allergen source	Allergen	Carrier	Year	Reference
Peptide carrier vaccines based on chemically-coupled allergen-derived peptides
Timothy grass pollen	Phl p 1	KLH	2001	Focke et al., FASEB J. [41]
Birch pollen	Bet v 1	KLH	2004	Focke et al., Clin. Exp. Allergy [42]
Olive pollen	Ole e 1	KLH	2011	Twaroch et al., J. Allergy Clin. Immunol. [45]
House dust mite	Der p 2	KLH	2012	Chen et al., Allergy [46]
Alternaria alternata	Alt a 1	KLH	2012	Twaroch et al., Clin. Exp. Allergy [47]
Timothy grass pollen	Phl p 5	KLH	2014	Focke et al., J. Allergy Clin. Immunol. [48]
Recombinant fusion proteins consisting of allergen-derived peptides fused to viral carrier proteins
Timothy grass	Phl p 1	VP1 (HRV)	2009	Edlmayr et al., J. Immunol. [49]
Cat	Fel d 1	PreS (HBV)	2011	Niespodziana et al., J. Allergy Clin. Immunol. [50]
Birch pollen	Bet v 1	PreS (HBV)	2013	Marth et al., J. Immunol. [51]
House dust mite	Der p 23	PreS (HBV)	2014	Banerjee et al., J. Immunol. [52]
Timothy grass pollen	Phl p 1, 2, 5, 6	PreS (HBV)	2015	Focke et al., J. Allergy Clin. Immunol. [53]

Abbreviations: HRV: Human rhinovirus; HBV: Hepatitis B virus.