Table 2. Advantages and possible applications of recombinant B cell epitope-based allergy vaccines.

Advantages High safety due to lack of allergenic activity Convenient treatment with few high dose injections possible due to lack of allergenic activity and good immunogenicity Can be easily manufactured under controlled conditions at low costs Tool box construction principle applicable to all allergen sources Well-defined mechanism of action Molecular tests for precise prescription and biomarkers for monitoring of treatment available Patient-tailored treatment based on individual prescriptions without need for extensive clinical trials may be possible due to defined uniform mode of action of individual components Suitable for prophylactic vaccination

Possible applications Therapeutic AIT for allergic rhinitis Long-term efficacy even after interruption of treatment PreS-based vaccines may protect also against HBV Therapeutic AIT for allergic asthma, atopic dermatitis, food allergy and venom allergy due to high safety, good immunogenicity and applicability of technology to all allergen sources Therapeutic AIT possible even in risky patients (e.g., pregnancy) due to high safety Prophylactic vaccination in children due to lack of sensitization: Prevention of progression from rhinitis to asthma Prevention of progression from silent IgE sensitization to allergy Prevention of IgE sensitization