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. Author manuscript; available in PMC: 2019 Feb 26.
Published in final edited form as: Neuron. 2008 Aug 14;59(3):475–485. doi: 10.1016/j.neuron.2008.07.006

Figure 2. Release probability is dendritically segregated.

Figure 2

(A, B) Images (left) and destaining curve fits (right) for synaptic contacts between a cell pair, on different (A) or same dendritic branches (B) of the postsynaptic neuron (axon is blue and dendrite is orange). Release probability of synapses in the same dendritic branch is very similar. (C) Summary of similarity comparisons between synapse pairs. Dashed line indicates expected mean difference due to chance from Monte Carlo simulations (1.15 SDs, Wilcoxon rank sum test for axon P = 0.1023, dendrite P < 0.0001). Mean intersynaptic distances were not significantly different (axon vs. dendrite, P = 0.1406, axon = 8.5 ± 5.3 μm (SD), dendrite = 5.9 ± 3.0 μm (SD)). (D) Normalized release probability plotted against number of synapses in the axonal branch (open circles) and in the dendritic branch (closed circles). pr homeostatically adapts to the number of synapses made by the presynaptic cell onto the same dendritic branch. Lines are linear fits to the data. Scale bars, 5 μm. Error bars are ± s.e.m.