Table 5.
Level 3 comparison of key amino acid residues in common water flea (Daphnia magna) ecdysone receptor (EcR) relative to other species. a, b
| Class Name | Scientific Name | Common Name | D506 | T537 | T540 | R577 | A592 | Y602 | N695 |
|---|---|---|---|---|---|---|---|---|---|
| Branchiopoda | Daphnia magna | common water fleas | D | T | T | R | A | Y | N |
| Branchiopoda | Daphnia pulex | common water flea | D | T | T | R | A | Y | - |
| Malacostraca | Crangon crangon | crustaceans | E | T | T | R | G | Y | N |
| Malacostraca | Portunus trituberculatus | swimming crab | E | T | T | R | G | Y | N |
| Malacostraca | Procambarus clarkii | red swamp crayfish | E | T | T | R | G | Y | N |
| Malacostraca | Scylla paramamosain | green mud crab | E | T | T | R | G | Y | N |
| Malacostraca | Neomysis integer | opossum shrimps | E | S | T | R | F | Y | N |
| Insecta | Bicyclus anynana | squinting bush brown | D | T | T | R | A | Y | N |
| Insecta | Locusta migratoria | migratory locust | E | T | T | R | A | Y | N |
| Insecta | Heliothis virescens | tobacco budworm | E | T | T | R | A | Y | N |
| Insecta | Aedes aegypti | yellow fever mosquito | E | T | T | R | A | Y | N |
| Insecta | Harmonia axyridis | ladybird beetles | E | T | T | R | V | Y | N |
| Insecta | Colaphellus bowringi | leaf beetles | E | T | T | R | V | Y | N |
| Insecta | Periplaneta americana | American cockroach | P | T | T | R | A | Y | N |
| Chilopoda | Lithobius peregrinus | centipedes | E | T | T | R | A | Y | N |
| Merostomata | Limulus polyphemus | Atlantic horseshoe crab | E | T | T | R | A | Y | N |
| Arachnida | Liocheles australasiae | scorpions | E | T | T | R | A | Y | N |
| Arachnida | Parasteatoda tepidariorum | common house spider | E | T | T | R | A | Y | N |
| Arachnida | Varroa destructor | honeybee mite | E | T | T | R | A | Y | N |
| Maxillopoda | Tigriopus japonicus | copepods | E | T | T | R | A | Y | N |
| Maxillopoda | Paracyclopina nana | copepods | E | T | T | R | A | Y | N |
| Collembola | Orchesella cincta | slender springtails | E | T | T | R | A | Y | - |
| Priapulidae | Priapulus caudatus | priapulids | E | T | T | R | G | Y | H |
| Eutardigrada | Ramazzottius varieornatus | water bears | E | T | T | R | A | Y | W |
| Enopleac | Trichuris trichiura | human whipworm | D | T | N | K | G | Y | H |
| Enopleac | Trichinella papuae | roundworms | D | T | N | K | G | Y | H |
| Lingulatac | Lingula anatina | lampshells | E | T | V | R | G | L | H |
a
Listing of all species investigated in Level 3 is provided (Supplementary Data).
b
Amino acids represented by acronyms is listed (Table 1).
c
Species predicted lesser likelihood of susceptibility to agonists of the EcR, but which possess identified ortholog candidates for EcR.