Table 3. Effect of IVM on pharyngeal pumping activity of wild-type, nhr-8 deficient and transgenic C. elegans strains.

	Pump frequency (Hz)
	Untreated	IVM 0.1 μM	IVM ratio
Bristol N2	4.5 ± 0.1	2.1. ± 0.2 a	2.4
AE501 nhr-8(ok186)	4.4 ± 0.1	0.3 ± 01 a, b	13.0
Cel-nhr-8 in AE501	4.5 ± 0.1	2.0 ± 0.1 a	2.2
Cel-pgp-6 in AE501	4.2 ± 0.1	2.4 ± 0.2 a	1.8
Hco-nhr-8 in AE501	4.6 ± 0.1	2.1 ± 0.2 a	2.1

Pump frequency recorded with the Nemametrix ScreenChip system. Mean ± SEM; n = 30–90 worms/group.

IVM potency ratio as pump frequency with no treatment / pump frequency following exposure with IVM at 0.1 μM.

^a p<0.001 vs untreated worms;

^b p<0.001 vs wild-type Bristol N2.