Table 2. GO annotation categories enriched in nuclear size mutants.

GO category		Nuclear size mutants		Background		Fold enrichment	p value
		Frequency	%	Frequency	%
GOBP	mRNA processing	8/33	24.2	96/3377	2.8	8.6	0.00057
	mRNA metabolic process	10/33	30.3	160/3377	4.7	6.5	0.00036
	RNA processing	12/33	36.4	258/3377	7.6	4.8	0.00059
	gene expression	20/33	60.6	849/3377	25.1	2.4	0.00355
GOCC	LINC complex	2/33	6.1	2/3377	0.1	61	0.00787
	Nem1-Spo7 phosphatase complex	2/33	6.1	2/3377	0.1	61	0.00787
	intracellular ribonucleoprotein complex	10/33	30.3	260/3377	7.7	3.9	0.00988
	ribonucleoprotein complex	10/33	30.3	260/3377	7.7	3.9	0.00988
	nuclear part	20/33	60.6	779/3377	23.1	2.6	0.00031
	protein complex	16/33	48.5	627/3377	18.6	2.6	0.00705
	macromolecular complex	27/33	81.8	1082/3377	32.0	2.6	3.87 x10-7

GO annotation categories enriched in genes deleted in 33 nuclear size mutants relative to background population of all essential and non-essential genes screened (p ≤ 0.01) are shown. Adjusted p values calculated using the Bonferroni multiple hypothesis testing correction method. GO biological process (GOBP) and GO cellular component (GOCC) are shown. No GO molecular function (GOMF) categories were significantly enriched. Enrichment analysis performed using GO::TermFinder [23] with PomBase annotations [24].