Table 2:

Association of Adult Offspring LDL-C with Parental LDL-C at Pre-Pregnancy Examinations Analyzed with a Continuous (a) and Dichotomous (b) Approach

OUTCOME:	PRE-PREGNANCY EXAM LEVEL:
	Maternal LDL-C (mg/dL)				Paternal LDL-C (mg/dL)
a) Adult Offspring LDL-C (mg/dL)	N	β	(95% CI)	p-value	N	β	(95% CI)	p-value
M1: adjusted for parental age, offspring age and sex	241	0.38	(0.27, 0.49)	<0.001	297	0.24	(0.12, 0.35)	<0.001
M2: M1 + adjusted for parental BMI and smoking, offspring BMI	241	0.35	(0.25, 0.46)	<0.001	297	0.25	(0.13, 0.38)	<0.001
M3: M2 + adjusted for offspring diet and physical activity	216	0.38	(0.27, 0.48)	<0.001	271	0.24	(0.10, 0.37)	<0.001
M4: M3 + adjusted for offspring LDL-C genetic risk score	209	0.32	(0.22, 0.42)	<0.001	263	0.13	(0.02, 0.25)	0.02
	Elevated Maternal LDL-C (>130 mg/dL)				Elevated Paternal LDL-C (>130 mg/dL)
b) Elevated Adult Offspring LDL-C (>130 mg/dL)	N	OR	(95% CI)	p-value	N	OR	(95% CI)	p-value
M1: adjusted for parental age, offspring age and sex	241	5.0	(2.2–11.2)	<0.001	297	1.9	(1.0–3.9)	0.06
M2: M1 + adjusted for parental BMI and smoking, offspring BMI	241	4.6	(2.0–10.6)	<0.001	297	2.0	(1.0–4.2)	0.07
M3: M2 + adjusted for offspring diet and physical activity	216	4.7	(1.8–12.1)	0.001	271	1.8	(0.8–4.0)	0.15
M4: M3 + adjusted for offspring LDL-C genetic risk score	209	3.8	(1.5–9.8)	0.005	263	1.8	(0.8–4.2)	0.18

^*LDL-C = low-density lipoprotein cholesterol, BMI = body mass index, β = linear model regression coefficient, SE = standard error, M# = model #.