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. 2019 Feb 26;8:e39476. doi: 10.7554/eLife.39476

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© 2019, Rinné et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — (a) Representative inside-out single channel recordings of TASK-3 at +140 and −140 mV before (left, black) and after (right, purple) application of 100 µM bupivacaine and (b) amplitude histogram of the events recorded at +140 mV (n = 4). (c) Change in relative open probability (NP_o) by 100 µM bupivacaine. (d) Graphical illustration of the open times before and (e) after drug application (n = 4). (f) Analyses of the closed time before and (g) after application of 100 µM bupivacaine (n = 4). (h) Representative inside-out single channel recordings of TASK-3 at +140 mV before (up, black) and after (down, light pink) application of 100 mM TEA and (i) representative illustration of the open times of a TASK-3 containing patch before and after drug application. (j) Relative change in open times by 100 mM TEA (n = 3). (k) Amplitude histogram of the events recorded at +140 mV (n = 3) and (l) the respective analyses of the relative change in single channel amplitude before (black) and after (light pink) application of 100 mM TEA. Data are represented as mean ± S.E.M.. The numbers of experiments (n) are indicated within the respective bars.

Figure 5—figure supplement 1. — (a) Representative inside-out single channel recordings of TASK-3 at +140 and −140 mV before (left, black) and after (right, purple) application of 100 µM bupivacaine and (b) amplitude histogram of the events recorded at +140 mV (n = 4). (c) Change in relative open probability (NP_o) by 100 µM bupivacaine. (d) Graphical illustration of the open times before and (e) after drug application (n = 4). (f) Analyses of the closed time before and (g) after application of 100 µM bupivacaine (n = 4). (h) Representative inside-out single channel recordings of TASK-3 at +140 mV before (up, black) and after (down, light pink) application of 100 mM TEA and (i) representative illustration of the open times of a TASK-3 containing patch before and after drug application. (j) Relative change in open times by 100 mM TEA (n = 3). (k) Amplitude histogram of the events recorded at +140 mV (n = 3) and (l) the respective analyses of the relative change in single channel amplitude before (black) and after (light pink) application of 100 mM TEA. Data are represented as mean ± S.E.M.. The numbers of experiments (n) are indicated within the respective bars.