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. 2019 Feb 18;129(3):1345–1358. doi: 10.1172/JCI123233

Figure 6. Monocyte/macrophage depletion inhibits adrenalectomy-induced SPEM development.

Figure 6

Immunostaining of stomach sections from the gastric corpus lesser curvature of mice euthanized 5 days after sham surgery or adrenalectomy, treated with empty liposomes (vehicle) or clodronate. Sections were probed for (A) CD68 (macrophages, green) or (B) ATP4B (parietal cells, red), GSII lectin (mucous neck cells, pink), or MIST1 (chief cells, green). Nuclei were labeled with DAPI (blue). Scale bars: 100 μm. (C) Quantitation of the number of CD68+ macrophages, parietal cells, or chief cells observed per ×20 field within the lesser curvature (n ≥ 7 mice/group). Data are mean ± SD; P values were determined by 1-way ANOVA with post hoc Tukey’s t test. ***P ≤ 0.0001.