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. 2019 Feb 18;129(3):1372–1386. doi: 10.1172/JCI124508

Figure 2. APs transferred miR-143, miR-145, and miR-223 into VSMCs, and promoted VSMC differentiation.

Figure 2

(A) Heatmap of the top 10 differentially expressed miRNAs in VSMCs cocultured with or without APs for 24 hours (n = 3). (B) Expression of miR-143, miR-145, and miR-223 in VSMCs (Ctrl) and VSMCs cocultured with APs (n = 4). (C) Expression of miR-143, miR-145, and miR-223 in VSMCs (Ctrl) and VSMCs cocultured with RPs or APs after pretreatment with prostacyclin or RNase A (n = 4). (D) The expression of ACTA2 and KLF4 in control VSMCs (Ctrl) and VSMCs cocultured with RPs or APs after pretreatment with prostacyclin or RNase A and thrombin (n = 4). Data are presented as mean ± SD. *P <0.05, **P < 0.01, ***P < 0.001 vs. Ctrl; †P < 0.05, ††P < 0.01 vs. RPs; #P < 0.05, ##P < 0.01 vs. APs. Statistical significance was determined using parametric t test (B) and 1-way ANOVA followed by Tukey-Kramer multiple-comparisons test (C and D).

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