Table 2.
Comparison of selected toxicities among different treatment arms in NAPOLI-1 study
| Number of patients with toxicity/grade 3 or 4 (%) | nal-IRI plus 5-FU and leucovorin N=117 (%) | nal-IRI monotherapy N=151 (%) | 5-FU and leucovorin N=149 (%) |
|---|---|---|---|
| Diarrhea | 69 (59)/15 (13) | 103 (70)/31 (21) | 35 (26)/6 (4) |
| Vomiting | 61 (52)/13 (11) | 80 (54)/20 (14) | 35 (26)/4 (4) |
| Anorexia | 52 (44)/5 (4) | 72 (49)/13 (19) | 43 (32)/3 (2) |
| Neutropenia | 46 (39)/32 (27) | 37 (25)/22 (15) | 7 (5)/2 (1) |
| Anemia | 44 (38)/11 (9) | 48 (33)/16 (11) | 31 (23)/9 (7) |
Notes: N is the number of patients enrolled in the treatment arms. Data adapted from Wang-Gillam et al.19
Abbreviations: 5-FU, 5-fluorouracil; nal-IRI, nanoliposomal-irinotecan.