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. 2019 Feb 21;12:1447–1454. doi: 10.2147/OTT.S173207

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© 2019 Wang et al. This work is published and licensed by Dove Medical Press Limited

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miR-935 downregulated IL-27 expression in NSCLC cells.

Notes: (A) IL-27 was predicted as a target gene of miR-935 by PicTar and TargetScan. (B) miR-935 overexpression reduced the mRNA levels of IL-27 in H1299 and A549 cells. (C) miR-935 overexpression reduced the protein levels of IL-27 in H1299 and A549 cells. (D) miR-935 suppressed the luciferase activity of IL-27 3′-UTR in H1299 and A549 cells. (E) miR-935 was overexpressed in NSCLC samples. (F) miR-935 expression was negatively associated with IL-27 protein levels in NSCLC tissues. **P<0.01.

Abbreviation: NSCLC, non-small-cell lung cancer.