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. 2019 Feb 11;129(3):1272–1277. doi: 10.1172/JCI124853

Figure 3. ApoE4 increases insoluble Aβ levels in the hippocampus of APP/PS1 mice depending on neuronal LRP1.

Figure 3

The concentrations of Aβ40 (A–C), Aβ42 (D–F), and apoE (G–I) in the hippocampus extracted in TBS, TBS-X, and GDN-HCl from APP/PS1; APOE3 control, APP/PS1; APOE3; nLrp1–/–, APP/PS1; APOE4 control, and APP/PS1; APOE4; nLrp1–/– mice were measured by ELISA at 9 months of age (n = 18–23/group). Horizontal lines, boxes, and whiskers correspond to median, IQR, and the furthest points within ×1.5 IQR from the box, respectively. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, Tukey-Kramer post hoc analysis of 2-way ANOVA. White circles, data from female mice; black circles, data from male mice.