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. 2019 Feb 15;14:1193–1212. doi: 10.2147/IJN.S190426

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© 2019 Na et al. This work is published and licensed by Dove Medical Press Limited

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(A) Ex vivo antiplatelet activity evaluation of raw TCG suspension and TCG-SM according to dose of 2, 5, and 10 mg/kg. (B) Dose–response curve for ADP-induced platelet aggregation in TCG according to time-points (2, 5, and 10 hours) after oral administration of raw TCG suspension and TCG-SM.

Notes: (A) Values are expressed as mean ± SEM (n=9). (B) ED₅₀ was defined as the dose of the drug that inhibits platelet aggregation to 50%. Values are expressed as mean ± SEM (n=9).

Abbreviations: ED₅₀, 50% effective dose; SEM, standard error of mean; TCG, ticagrelor; TCG-SM, ticagrelor-loaded self-microemulsifying drug delivery system.