Table S3.
The experimental composition and observed responses through Scheffé’s mixture design
| Run | Factors | Responses | |||||
|---|---|---|---|---|---|---|---|
| X1 | X2 | X3 | Y1 | Y2 | Y3 | Y4 | |
| Capmul MCM (w/w %) | Cremophor EL (w/w %) | Transcutol P (w/w %) | Solubility (mg/mL) | Precipitation (%) | Droplet size (nm) | Transmittance (%) | |
| 1 | 24.8307 | 65.1693 | 10 | 169.4±0.93 | 30.9±11.2 | 152.3±12.4 | 96.7±0.02 |
| 2 | 10 | 25.8795 | 64.1205 | 279.1±1.94 | 17.2±0.9 | 525.9±23.8 | 66.1±0.59 |
| 3 | 10 | 10 | 80 | 330.59±0.93 | 66.3±0.9 | 894.9±34.1 | 49.5±0.37 |
| 4 | 24.9753 | 46.7603 | 28.2644 | 188.7±0.91 | 9.4±0.4 | 218.3±14.8 | 89.2±0.11 |
| 5 | 38.6 | 38.2553 | 23.1447 | 165±3.85 | 13.1±0.4 | 306.7±25.6 | 79.6±0.48 |
| 6 | 10 | 10 | 80 | 316.05±3.55 | 67.7±0.3 | 1,023.6±85.1 | 50.3±0.52 |
| 7 | 10 | 62.3288 | 27.6712 | 211.71±2.63 | 21.7±0.4 | 98.8±5.7 | 98.4±0.06 |
| 8 | 24.9753 | 46.7603 | 28.2644 | 194.85±1.76 | 16.5±1.5 | 214.7±15.6 | 89.2±0.06 |
| 9 | 40 | 50 | 10 | 126.51±1.98 | 7.2±0.4 | 234.6±21.4 | 92.9±0.10 |
| 10 | 10 | 80 | 10 | 148.28±2.67 | 6.3±0.3 | 54.7±8.6 | 99.2±0.02 |
| 11 | 24.8307 | 65.1693 | 10 | 129.27±3.39 | 0.2±3.2 | 189.5±11.9 | 93.1±0.04 |
| 12 | 32.9684 | 10 | 57.0316 | 237.49±2.70 | 18.8±0.4 | 631.8±32.2 | 54.8±0.42 |
| 13 | 23.9412 | 27.95 | 48.1089 | 254.79±1.41 | 13.6±0.0 | 372.3±24.7 | 64.9±0.35 |
| 14 | 32.9684 | 10 | 57.0316 | 231.22±2.66 | 21±0.1 | 686.2±34.5 | 56.3±0.28 |
| 15 | 10 | 45.642 | 44.358 | 239.32±1.42 | 12.2±0.4 | 129.9±11.8 | 94.1±0.11 |
| 16 | 40 | 25.75 | 34.25 | 191.07±1.32 | 16.2±0.3 | 884.0±64.8 | 55.3±0.43 |
| 17 | 24.9753 | 46.7603 | 28.2644 | 187.13±2.60 | 7.0±0.2 | 225.8±21.0 | 93.2±0.07 |
Note: Values are expressed as mean ± SD (n=3).