Table 4.
Predicted values and actual values of optimized TCG-SM
| Optimized factors | Response | Goal | Importance | 95% Cl low predicted value | Predicted value | 95% Cl high predicted value | Actual value | Error percentage (%) |
|---|---|---|---|---|---|---|---|---|
| X1: 10.0% X2: 53.8% X3: 36.2% |
Y1: Solubility (mg/mL) | Maximize | +++ | 212.01 | 222.32 | 232.62 | 236.2±3.6 | 6.25 |
| Y2: Precipitation (%) | Minimize | +++ | −4.0 | 10.4 | 24.7 | 10.6±0.3 | 2.50 | |
| Y3: Droplet size (nm) | Minimize | +++ | 25.6 | 116.7 | 207.8 | 110.2±2.6 | 5.61 | |
| Y4: Transmittance (%) | Maximize | +++ | 90.7 | 95.3 | 99.8 | 96.6±0.2 | 1.36 |
Note: Values are expressed as mean ± SD (n=3).
Abbreviations: TCG-SM, ticagrelor-loaded self-microemulsifying drug delivery system; CI, confdence interval.