Table 6.
Ex vivo pharmacodynamic parameters of TCG in rats after oral administration of raw TCG suspension and TCG-SM with dose of 2, 5, and 10 mg/kg
| Samples | Dose (mg/kg) | Pharmacodynamic parameters | |||
|---|---|---|---|---|---|
| AUIC0–24 (%⋅hours) | ED50 (mg/kg) | ||||
| 2 hours | 5 hours | 10 hours | |||
| Raw TCG suspension | 2 | 119.9±86.7 | 5.1 | 4.5 | 8.4 |
| 5 | 444.3±205.7 | ||||
| 10 | 907.0±408.8 | ||||
| TCG-SM | 2 | 270.4±113.3* | 3.5 | 2.5 | 4.4 |
| 5 | 907.8±200.5* | ||||
| 10 | 1,254.0±233.9* | ||||
Notes:
*
P<0.05 vs raw TCG suspension of same dose. Values are expressed as mean ± SD (n=9).
Abbreviations: AUIC, area under the inhibitory curve; ED50, 50% effective dose; TCG, ticagrelor; TCG-SM, ticagrelor-loaded self-microemulsifying drug delivery system.