Figure 4.
Comparison of T47D-WT-inoculated group and T47D-17β-HSD1-inoculated group when different levels of E1 are administered.
Notes: Vehicle (0 µg/kg/day) (A); low dose of E1 (0.1 µg/kg/day) (B); intermediate dose of E1 (0.5 µg/kg/day) (C); high dose of E1 (2.5 µg/kg/day) (D). When treated with the intermediate level of E1, tumor growth showed a significantly greater difference between the T47D-WT-inoculated group and T47D-17β-HSD1-inoculated group. Values are expressed as mean ± SD. *P<0.05; ***P<0.001; n=5 or 8.
Abbreviations: E1, estrone; NS, not significant.