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. 2019 Feb 13;14:1119–1130. doi: 10.2147/IJN.S188970

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© 2019 Lin et al. This work is published and licensed by Dove Medical Press Limited

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Enzymatic activity of delivered βG in vivo.

Notes: (A) The activity of LPPC-delivered βG in the liver was determined. The livers were sectioned for staining of βG activity with X-gluc (in blue). (B) Biodistribution of LPPC/βG by measuring the concentration of βG. BALB/c mice were intravenously injected with free βG, empty LPPC, or LPPC/βG for 48 hours. Mice were sacrificed, and the organs were collected. The concentration of βG in various organs was analyzed.

Abbreviations: βG, β-glucuronidase; LPPC, liposomes containing polyethylenimine and polyethylene glycol complex.