Skip to main content
. 2019 Feb 18;14:1213–1227. doi: 10.2147/IJN.S196681

Figure 1.

Figure 1

Particle size frequencies and solubility of indomethacin in IMC-NPs.

Notes: Particle size frequencies of indomethacin in IMC-MPs (A) and IMC-NPs (B) as determined by a laser diffraction particle size analyzer. (C) Particle size frequencies of indomethacin in IMC-NPs by the dynamic light scattering method. (D) AFM image of indomethacin in IMC-NPs by the SPM-9700. (E) Solubility of indomethacin in IMC-NPs. n=8. *P<0.05 vs IMC-MPs. The ophthalmic formulation containing 35–200 nm sized indomethacin nanoparticles was prepared by treatment with a bead mill. The drug solubility in IMC-MPs and IMC-NPs was higher than that in IMC-MPs at 84.5 µM and 363.2 µM, respectively.

Abbreviations: IMC-MPs, ophthalmic formulation containing indomethacin microparticles; IMC-NPs, ophthalmic formulation containing indomethacin nanoparticles.