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. 2019 Feb 18;14:1213–1227. doi: 10.2147/IJN.S196681

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© 2019 Nagai et al. This work is published and licensed by Dove Medical Press Limited

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Effect of endocytosis pathways on transepithelial penetration of IMC-NPs in HCE-T cell monolayers.

Notes: Effects of endocytosis inhibitors on the TER (A), accumulation (C) and penetration (E) of indomethacin in HCE-T cell monolayers treated with IMC-NPs. Changes in TER (B), accumulation (D) and penetration (F) of indomethacin in HCE-T cell monolayers treated with IMC-NPs by multi-treatment with nystatin, dynasore and rottlerin (Nys+Dyn+Rot). (G and H) Effect of endocytosis inhibitors on the number of indomethacin nanoparticles in the basolateral side. n=5–8. *P<0.05 vs vehicle for each category. The penetration of indomethacin was significantly decreased by the combination of nystatin, dynasore and rottlerin.

Abbreviations: IMC-NPs, ophthalmic formulation containing indomethacin nanoparticles; con, concentration.